Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus

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Blue rubber bleb nevus syndrome: successful treatment with sirolimus.

Blue rubber bleb nevus syndrome (BRBNS) is a rare disorder with characteristic vascular malformations of the skin, gastrointestinal system, and, less often, other organ systems. The characteristic cutaneous lesions consist of deep-blue, soft, rubbery blebs, which are easily compressible. The most serious complication is abundant gastrointestinal bleeding. We describe the case of an 8-year-old g...

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Blue Rubber Bleb Nevus Syndrome: Promising Response To Sirolimus.

BACKGROUND Blue rubber bleb nevus syndrome is a rare disease involving venous malformations. CASE CHARACTERISTICS We present a 6-year-old female with the syndrome, and consumptive coagulopathy. INTERVENTION/OUTCOME After management with sirolimus, symptoms resolved. MESSAGE Sirolimus may be a valuable option for reducing bleeding complications and cosmetic sequelae for the patients with t...

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[Blue rubber bleb nevus syndrome].

The blue rubber nevus syndrome consists of multiple venous malformations in the skin and gastrointestinal tract associated with intestinal hemorrhage and iron deficiency anemia. Other organs may be involved. The causes of this syndrome are unknown. Its most common presentation is in the form of sporadic cases, but dominant autosomal inheritance has been described. It is a condition that affects...

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Blue rubber bleb nevus syndrome.

A 61-year-old woman who had hypertension and diabetes presented to the gastroenterology clinic with profound fatigue and malaise of about 6 months’ duration. She denied any chest pain, shortness of breath, hematochezia, melena, hematemesis, or constitutional symptoms. The patient reported no new prescriptions, over-the-counter medications, or herbal supplements. She said that a screening colono...

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Blue rubber bleb nevus syndrome: case report.

The case of a patient with blue rubber bleb nevus syndrome who is infected by acquired immunodeficiency syndrome virus due to multiple blood transfusions is presented. This case shows that although it is a rare systemic disorder, blue rubber bleb nevus syndrome has to be considered in the differential diagnosis of chronic anemia or gastrointestinal bleeding. Patients should be investigated by e...

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ژورنال

عنوان ژورنال: Case Reports in Pediatrics

سال: 2018

ISSN: 2090-6803,2090-6811

DOI: 10.1155/2018/7654278